In detail

The extraction solvent determines the solvent risk. Water and ethanol are low-risk; hexane, ethyl acetate, and methanol require tighter controls. Regulatory and pharmacopoeial frameworks group solvents by toxicity class and set permitted daily exposure or concentration limits. The certificate should test the solvents the process could plausibly leave behind.

A generic 'residual solvents: complies' statement is weak. Ask for the solvent panel, the limits, and the results. If the extract is spray-dried on a carrier, the carrier process is part of the picture too, and the carrier should be declared on the TDS.

Why it matters to a buyer

  • Solvent residues are a common audit finding for botanical ingredients.
  • The panel should match the extraction system, not a template.
  • Carrier and drying method affect what needs to be tested.

What to ask a supplier

01

Which solvents were used in extraction and drying?

02

Which solvent classes and limits were applied?

03

Can you provide the individual results, not only a compliance statement?

References and further reading

External links are provided for orientation. Requirements differ by market, product, and dose; confirm with your regulatory advisor.

Cite this page

Rainwood Botanical. "Residual solvents." Botanical extract glossary, October 2026. https://ingredients.rainwoodbio.com/resources/glossary/residual-solvents/